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BIG NEWS!second HIV patient cured.

The exact method that’s now cured two men of HIV infection is not one that’s going to be widely available to the nearly 38 million people worldwide living with the virus, experts say.

Still, the news has rekindled hopes of finally winning the war against the virus that causes Aids.

The Berlin and London patients benefited from a combination of medical and genetic chance, the experts explained. And even with luck on their side, the two men had to undergo a grueling treatment that could easily have killed them.

“There are a number of circumstances that limit the applicability of this to people around the world,” said Rowena Johnston, vice president and director of research at amfAR, The Foundation for AIDS Research.

But the two cases – along with a third reported cure in Düsseldorf, Germany – point the way to a potential genetic cure for HIV, Johnston said.

“It’s a long way away. I’m not saying that’s happening tomorrow. But it gives you the sense that it might be worth putting in the effort to see if we can develop the technologies to make that happen,” Johnston said.

Genetic mutation

The “London patient”, 40-year-old Adam Castillejo, had a bone marrow transplant designed to beat an otherwise untreatable blood cancer called Hodgkin’s lymphoma, just as his “Berlin patient” predecessor Timothy Ray Brown did to cure his leukemia.

In both cases, the critical transplant came from a donor with a mutation in a protein found on the surface of white blood cells called CCR5.

“HIV uses this protein to gain entry into the cells it infects,” Johnston said. “If you’re a person with this genetic mutation, which means you don’t have that protein, it’s almost impossible for HIV to infect any of your cells.”

As a result, the two men essentially received a new immune system with a built-in genetic resistance to HIV. Doctors theorise that whatever HIV was left hiding in their systems after the treatment wilted away because it had nowhere left to spread.

“Even if the virus wants to go out and find a cell to infect, there are no cells it can infect, so it just dies out,” Johnston said. “That’s one thought of how this transplant system works.”

Numerous problems

The problems with applying this exact cure to everyone now living with HIV are numerous.

For one thing, it involves a bone marrow transplant that wipes out a person’s immune system – a radical procedure reserved for people with fatal conditions that aren’t responding to other treatments, said Dr Antonio Urbina, medical director at the Institute for Advanced Medicine at Mount Sinai, in New York City.

“This patient went through a lot, in terms of the stem cell transplant and all of the complications that can be incurred from that,” he said. “This is something that could have a high patient mortality. To scale that up to other patients would be difficult.”

Furthermore, the patient has to have a bone marrow-matched donor who carries this specific mutation in the CCR5 protein, Urbina and Johnston noted.

This very rare mutation typically only occurs in people with northern European or Caucasian ancestry, the experts said.

“In this case, what was unique was even though the patient was from South Africa, his ancestry was partially Dutch, and they were able to find a German donor who was a match genetically for this patient,” Urbina said.

As a result, this specific cure is not going to be useful in more than a handful of patients, Urbina said.

But there are important lessons to be learned from the men cured of HIV infection in this way.

Not a miracle

Twelve years passed after the announcement of the Berlin patient’s cure, and those were years spent wondering whether Brown had benefited from a freak accident of treatment, Johnston said.

“Certainly in that amount of time you can start to wonder what strange set of unrepeatable circumstances happened in the case of the Berlin patient,” she said. “Now that it’s happened again in the London patient, we are getting the sense there was nothing miraculous or weird or once-in-a-lifetime about the Berlin patient. This really is possible.”

Even better, there’s also now a third case – a patient in Düsseldorf who had a bone marrow transplant and now appears to be HIV-free, Johnston said. Researchers continue to follow this third patient.

The Berlin and London patients both were born with different versions of the CCR5 protein, so their successful treatment also shows that their original genetics don’t matter as long as the genes are replaced with the HIV-resistant mutation, she added.

All of this points toward a potential gene therapy cure for HIV, Johnston said.

Fruitful way forward

“Let’s say you could take my stem cells, put them in a dish, give my cells that genetic mutation and infuse them back into me,” she said. “Since we now have a pretty good sense that this mutation might be very important, then we have a very good idea that could be a very fruitful way forward.”

Even better, doctors could one day potentially create an injectable cure that would add this gene mutation on the fly.

“What if we could work out a way of doing gene therapy that actually you would inject into the person’s arm the actual gene therapy tools, and then they would seek out the cells they need to do the editing on and do it inside the cells of the person,” Johnston said.

Such a cure would not only clear HIV from a person’s system, but potentially would make them immune from further infection, she said.

“This is actually going the whole way, removing all of the infectious virus from a person’s body,” Johnston said. “It might actually make these guys, now that they have immune systems that don’t have the CCR5 vulnerability, it might actually almost eliminate the possibility they would ever be HIV-infected for more information

EMAIL US cadilm@yahoo.com

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Billionaire E- money gives out cars to his employees on his 39th birthday

Emeka Okonkwo popularly known as E Money is the CEO of Five Star Group Of Companies which includes the infamous Five Star Records that houses his elder brother, singer Kingsley Okonkwo Kcee.

E money has always been characterized by his selfless nature and his excessive love of the act of giving, severally he has been in the news for changing the life of one person or the other. E money is a father of three, his marriage to his wife, Juliet Okonkwo has spanned for roughly 10 years unlike Kcee who remains single till now.

E money is known for his flashy lifestyle, his love for the expensive and his taste of luxury. His fleet of cars are not easily rivaled by any rich person neither is the quality of his various mansions easily beatable.

E money proves he is as selfless as people claim today as he celebrates his 39th birthday giving out cars to loyal staffs of his establishment, Five Star.

Check out photos of the cars:

BIG STORY!Amber Rose gives Birth

a man holding a baby: Alexander A.E. Edwards and his baby son (c) Instagram
© Bang Showbiz Alexander A.E. Edwards and his baby son (c) Instagram

Amber Rose has given birth to a baby boy.

The 35-year-old model – who already has six-year-old son Sebastian with ex-husband Wiz Khalifa – and her partner Alexander ‘A.E.’ Edwards welcomed Slash Electric Alexander into the world on Thursday (10.10.19).

A.E. shared a photo of himself cradling his baby son on Instagram and paid tribute to his partner.

FILE: Amber Rose is seen on September 24, 2019 in Los Angeles, California.
© BG002/Bauer-Griffin/GC Images FILE: Amber Rose is seen on September 24, 2019 in Los Angeles, California.

He captioned the picture: “Slash Electric Alexander Edwards.. the world is urs now [heart emoji].

“Thank u @amberrose for loving me so much that u put ur body thru it 2 bring my sun in2 the world. I could never be as strong as u. Slash a rockstar [heart emoji (sic).”

Amber shared a series of videos from the delivery room on her Instagram story, featuring the rapper wearing scrubs alongside the caption “It’s time”, and a number of clips of him playing rock, paper, scissors with Sebastian.

Amber announced her pregnancy on social media in April by posting a picture of herself whilst having a scan, and wrote: “@ae4president and I are SUPER excited to announce that we have a Sweet little Baby Boy on the way! P.S Sebastian is soooooo Happy to be a big brother! (sic)”

Whilst Alexander added in his own post: “Even when it’s dark.. my SON will shine. Thank u baby 4 my greatest gift…I love you … I can’t wait to thug it out w my baby boy. & baby boy, I promise I won’t get mad if ur first words r “where the bitches @?” [laughing emoji] ( jokinggg-no hyper-masculinity) (sic)”

The Slutwalk founder suffered with Hyperemesis, extreme morning sickness, in both her pregnancies.

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I will be the Biafran president on july 30th-Benjamin onwoka

•Self-acclaimed Biafran president, Barr Benjamin Onwuka
•Self-acclaimed Biafran president, Barr Benjamin Onwuka

 

Self-acclaimed Biafran president, Barr. Benjamin Onwuka has renewed his agitation for Biafra barely 24 hours after he was released from prison.

It could be recalled that Barr. Onwuka was arrested on August 20, 2018, in Enugu state by security operatives, kept incommunicado for several months and was later transferred to Owerre Prisons from where he was released on July 1, 2019.

Addressing journalists shortly after he arrived Enugu, Onwuka said he had become more strengthened in his push for Biafra.

Barr. Onwuka who is the leader of Biafran Zionist Federation, BZF, claimed that with the support of the United States, his inauguration as Biafra President would take place on July 30, at the Michael Okpara Square, Enugu.

Onwuka equally claimed that while in detention, a meeting was held between him and President Muhammadu Buhari, where he told the President that there was no going back on Biafra.

He declared: “I am happy to inform our people that our victory is here. I have always said it that they cannot stop us. They took me on the 20th of August, 2018, and dumped me at an underground cell in Aso Drive, Abuja. I spent 3 months and 4 days inside that terrible place.

“Throughout that period, I was fed with a slice of bread in the morning, a spoon of rice in the afternoon, and few lobes of semovita in the night.

“From there, they later took me to Owerri Prison where I spent 7 months, before I was finally released on July 1.

“The craziest part of it is that I was not charged of anything. When they brought me before the court in Owerri, the judge said that I jumped earlier bail granted to me. But I wonder how someone being held inside underground cell jumped bail.

“However, all that is now history; we are marching forward and that is why I am asking all Biafrans to turn out en-masse on July 1 for the inauguration of Biafra government.

On the claims that he met Buhari while in detention, Onwuka said, “at the meeting facilitated by the US, I told Buhari that there was no going back on Biafra. I chronicled before him all the injustice and marginalization Biafrans are facing and made him to understand that Biafra is a different entity and has nothing to do with Nigeria.”

The Zionists leader, who equally spoke on the controversial Ruga proposal, warned that such would not be tolerated in any of the ‘Biafra areas’. According to him, “the Nigeria Government should limit its Ruga, or whatever they call it to ten States. They include Zamfara, Kebbi, Sokoto, Katsina, Jigawa, Kano, Bauchi, Gombe, Borno and Yobe States. Any other place outside these ten is a no-go-area.

“We are sending this clear warning because this is nothing but another push towards the realization of the on-going islamization agenda in the country. We are not going to allow it from Southern Kaduna, down to the entire Southern States.”

Asked whether he was not afraid of being taken back to the prison, Onwuka said, “I’m prepared to go back to prison again but it will be at their own cost.”

Big Brother Naija starts on sunday

Big Brother Naija 2019 Starts On Sunday

As the latest Big Brother Naija episode makes its highly anticipated premiere on Sunday, MultiChoice Nigeria has upped the ante with the announcement of N60million worth of prizes for the winner. This was unveiled recently by the organisers.

The breakdown of the prizes for the winner includes a N30million cash prize; a top range SUV from Nigerian automaker, Innoson Motors; a trip to Dubai for two packaged by TravelBeta; a home make-over courtesy of Scanfrost; a year’s supply of Pepsi drinks for a year and One Africa Fest VVIP experience; supply of Indomie noodles and Munch it for a year, and a brand new Oppo mobile smartphone. There’s also a bonus prize of two VIP Tickets to watch a European Football final game live, courtesy BET9ja. This season’s grand prize is an increase from the previous edition, which saw Miracle Ikechukwu Igbokwe walking away with N45m worth of prizes.

Speaking on the increased prize money, the Chief Executive Officer, MultiChoice Nigeria, Mr. John Ugbe said: “Each edition of Big Brother Naija significantly improves on all aspects of the previous season and this year is no different. The winner of Season Four will walk away from the House with a N30m cash prize and a top-of-the range SUV amongst many other exciting prizes. The Big Brother Naija winner will also emerge as the most popular and marketable personality on the continent, as the show is known to launch prominent careers in arts, entertainment and other supporting industries.”

Apart from the new and improved grand prize, another major development for this year’s edition of Big Brother Naija is the return of the House to Nigeria. While the location of the house has not been revealed, fans of the show have nonetheless been excited since the announcement was made earlier this year.

Already, millions of fans are already discussing the various segments of the show that they would love to watch, including the Saturday night parties, eviction shows, among others. Other fans are also wondering about what the characters of the latest housemates would be like, after popular housemates from last season. In the last edition, Cee C, Tobi, Miracle, Alex and Co, broke headlines with their many confrontations.

According to statistics available online, this year’s edition may be the biggest yet, judging from viewers expectations and comments on social media. Big Brother Naija Season 4 will run for 12 weeks.

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